期刊
CELL COMMUNICATION AND ADHESION
卷 8, 期 4-6, 页码 361-+出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/15419060109080754
关键词
connexin26; connexin36; gap junction; hemichannel; horizontal cell
资金
- NEI NIH HHS [R01 EY014127, R01 EY014127-03, R01 EY014127-02, R01 EY014127-04, R01 EY014127-01A2] Funding Source: Medline
- NIGMS NIH HHS [R01 GM037751-20, R01 GM037751-18, R01 GM037751-21, R01 GM037751-17, R01 GM037751-22, R01 GM037751-15, R01 GM037751-14, R01 GM037751-23, R01 GM037751, R01 GM037751-13, R01 GM037751-19, R01 GM037751-16] Funding Source: Medline
- NATIONAL EYE INSTITUTE [R01EY014127] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM037751] Funding Source: NIH RePORTER
Gap junctions between neurons function as electrical synapses, and are present in all layers of mammalian and teleost retina. These synapses are largest and most prominent between horizontal cells where they function to increase the receptive field of a single neuron beyond the width of its dendrites. Receptive field size and the extent of gap junctional coupling between horizontal cells is regulated by ambient light levels and may mediate light, dark adaptation Furthermore. teleost horizontal cell gap junction hemichannels may facilitate a mechanism of feedback inhibition between horizontal cells and cone photoreceptors, As a prelude to using mouse genetic models to study horizontal cell gap junctions and hemichannels. we sought to determine the connexin complement of mouse horizontal cells, Cx36, Cx37, Cx43, Cx45 and Cx57 mRNA could be detected in mouse retina by RT-PCR. Microscopy was used to further examine the distribution of Cx26 and Cx36. Cx26 immunofluorescence and a beta-gal reporter under regulatory control of the Cx36 promoter did not colocalize with a horizontal cell marker, indicating that these genes are not expressed by horizontal cells. The identity of the connexin(s) forming electrical synapses between mouse horizontal cells and the connexin that may form hemichannels in the horizontal cell telodendria remains unknown.
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