期刊
JOURNAL OF FORENSIC SCIENCES
卷 61, 期 1, 页码 254-258出版社
WILEY
DOI: 10.1111/1556-4029.12918
关键词
forensic science; forensic toxicology; nitrite; blood; ion chromatography; electrochemical detection; intoxication
资金
- National Natural Science Foundation of China [81302614]
- Science and Technology Commission of Shanghai Municipality [13ZR1443000, 14DZ2270800]
- Ministry of Finance, PR China [GY2013G-7]
Although nitrite is widely used in meat processing, it is a major toxicity hazard to children and is responsible for the bluebaby syndrome. A simple and effective method to determine nitrite in whole blood has been devised using ion chromatography with suppressed conductivity detection. The blood sample was deproteinized by adding acetonitrile and purified with mini-cartridges to remove hydrophobic compounds, chloride ions, and metal ions. An aliquot of the filtrate was injected onto the ion chromatography. The retention time for nitrite was 13.8 min and the detection limit of nitrite in whole blood was 0.4 mu mol/L. The calibration curve was linear (r(2) = 0.9999) over the concentration working range. The blood nitrite concentration of a victim who attempted suicide by ingesting sodium nitrite powder was determined using the present method. The basal levels for nitrite in human blood was determined with 7.1 +/- 0.9 mu mol/L (n = 12).
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