期刊
RESPIRATORY RESEARCH
卷 2, 期 1, 页码 20-26出版社
BIOMED CENTRAL LTD
DOI: 10.1186/rr34
关键词
association studies; chronic obstructive pulmonary disease; emphysema; genetics; lungs
资金
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL061575] Funding Source: NIH RePORTER
- NHLBI NIH HHS [HL-61575] Funding Source: Medline
Chronic obstructive pulmonary disease (COPD) is a significant cause of global morbidity and mortality. Previous studies have shown that COPD aggregates in families, suggesting a genetic predisposition to airflow obstruction. Many candidate genes have been assessed, but the data are often conflicting. We review the genetic factors that predispose smokers to COPD and highlight the future role of genomic scans in identifying novel susceptibility genes.
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