期刊
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
卷 7, 期 -, 页码 5S-7S出版社
CARDEN JENNINGS PUBL CO LTD
DOI: 10.1053/bbmt.2001.v7.pm11777102
关键词
respiratory virus infection; stem cell transplantation; ribavirin
The frequency of and survival from community-acquired respiratory virus (CRV) infections among patients undergoing allogeneic or autologous stem cell transplantation (SCT) were evaluated in a prospective study conducted at 37 medical centers affiliated with the European Group for Blood and Marrow Transplantation. Of the 40 CRV infections diagnosed in 1863 patients (739, allogeneic SCT; 1124, autologous SCT), 20 were attributed to respiratory syncytial virus (RSV), 4 to parainfluenza viruses, and 16 to influenza virus A. The overall survival rate among SCT recipients with CRV infections was 76%; 8 patients, all recipients of allogeneic transplants, died after diagnosis of CRV infection, but only 5 of these deaths (3, RSV; 2, influenza A virus) were attributable to the infection. The overall rate of death directly attributable to RSV and influenza A virus infections in allogeneic SCT recipients was 1.1%. In an 18-month extension, an additional 53 patients with CRV were identified. Results for the combined data were similar to those from the first phase of the study.
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