期刊
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
卷 16, 期 1, 页码 59-61出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00004850-200101000-00008
关键词
hippocampal atrophy; hyponatremia; SIADH; valproate
We report the case of a 62-year-old man who was administered sodium valproate (VPA) and who subsequently developed the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). He had been taking VPA for treatment of idiopathic generalized tonic-clonic convulsions since he was 56 years old. After substituting VPA with zonisamide, the serum sodium level returned to normal. We consider this episode of SIADH to be the result of a combination of factors including a weakness of the central nervous system and the long-term administration of VPA. Int Clin Psychopharmacol 16:59-61 (C) 2001 Lippincott Williams & Wilkins.
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