期刊
STEM CELLS
卷 19, 期 4, 页码 279-286出版社
ALPHAMED PRESS
DOI: 10.1634/stemcells.19-4-279
关键词
HIF-1; hemangioblast; hypoxia; hematopoietic development; vascular development
资金
- NHLBI NIH HHS [HL63310, K01 HL073153] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [K01HL073153] Funding Source: NIH RePORTER
Decreased oxygen (O-2) levels activate hypoxia-inducible factor (HIP-I) to induce genes involved in glycolysis, glucose transport, erythropoiesis, and angiogenesis. Mutations in various HIF-1 subunits have contributed to our understanding of the role hypoxia plays during early embryonic development in general and the cardiovascular system in particular. We propose that HIF-1 is important for the generation, proliferation, maintenance, and differentiation of the early cardio vascular system. Understanding aberrations in these hypoxic responses is important since they contribute to serious human disease such as ischemia and tumorigenesis. In this review we will focus on the critical role of O-2 in regulating cardiovascular events during early embryonic development.
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