期刊
BREAST CANCER RESEARCH
卷 3, 期 2, 页码 122-133出版社
BIOMED CENTRAL LTD
DOI: 10.1186/bcr284
关键词
cell growth inhibition; mammary epithelial cells; suberoylanilide hydroxamic acid
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资金
- NCI NIH HHS [CA-11944, R01 CA011944] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA011944] Funding Source: NIH RePORTER
The mechanism of suberoylanilide hydroxamic acid in cell growth inhibition involved induction of pRb-2/p130 interaction and nuclear translocation with E2F-4, followed by significant repression in E2F-1 and PCNA nuclear levels, which led to inhibition in DNA synthesis in mammary epithelial cell lines.
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