期刊
JOURNAL OF BIOMEDICAL SCIENCE
卷 8, 期 1, 页码 37-43出版社
BMC
DOI: 10.1007/BF02255969
关键词
ethanol; oxidative neuronal damage; resveratrol; polyphenols
资金
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [P01ES010535] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [R01AA006661, R01AA002054] Funding Source: NIH RePORTER
- NIAAA NIH HHS [AA06661, AA02054] Funding Source: Medline
- NIEHS NIH HHS [1 PO1 ES10535] Funding Source: Medline
There is strong evidence showing that chronic and excessive ethanol consumption may enhance oxidative damage to neurons and result in cell death. Although not yet well understood, ethanol may enhance ROS production in brain through a number of pathways including increased generation of hydroxyethyl radicals, induction of CYP2E1, alteration of the cytokine signaling pathways for induction of iNOS and sPLA(2), and production of prostanoids through the PLA(2)/COX pathways. Since many neurodegenerative diseases are also associated with oxidative and inflammatory mechanisms in the brain, it would be important to find out whether chronic and excessive ethanol consumption may exacerbate the progression of these diseases. There is evidence that the polyphenolic antioxidants, especially those extracted from grape skin and seed, may protect the brain from neuronal damage due to chronic ethanol administration. Among the polyphenols from grapes, resveratrol seems to have unique antioxidant properties. The possible use of this compound as a therapeutic agent to ameliorate neurodegenerative processes should be further explored. Copyright (C) 2001 National Science Council. ROC and S. Karger AG. Basel.
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