Monoamine Oxidase- w- Transaminase Cascade for the Deracemisation and Dealkylation of Amines

Herein we report a one-pot protocol for the deracemisation of chiral benzylic amines employing a novel monoamine oxidase--transaminase cascade, allowing access to enantiopure compounds in >99%ee. We also demonstrate that the same enzymatic cascade can be employed for the dealkylation of secondary amines with >99% conversion.