期刊
BREAST CANCER RESEARCH
卷 3, 期 5, 页码 328-331出版社
BIOMED CENTRAL LTD
DOI: 10.1186/bcr316
关键词
bioreductive drugs; hypoxia; hypoxia responsive element; reductase enzymes
类别
资金
- Medical Research Council [G0500366] Funding Source: Medline
Conclusive research has shown that regions of acute/chronic hypoxia, which exist within the majority of solid tumours, have a profound influence on the therapeutic outcome of cancer chemotherapy and radiotherapy and are a strong prognostic factor of disease progression and survival. A strong argument therefore exists for assessing the hypoxic fraction of tumours, prior to patient treatment, and to tailor this treatment accordingly. Tumour hypoxia also provides a powerful physiological stimulus that can be exploited as a tumour-specific condition, allowing for the rationale design of hypoxia-activated anticancer drugs or novel hypoxia-regulated gene therapy strategies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据