Synthesis and Peroxidase-Like Activity of Salt-Resistant Platinum Nanoparticles by Using Bovine Serum Albumin as the Scaffold

A green approach is proposed for the synthesis of Pt nanoparticles (PtNPs) in the bovine serum albumin (BSA) scaffold through biomineralization. The resulting BSA-PtNPs have been proved to function as peroxidase mimics that can catalyze the reaction of various peroxidase substrates in the presence of H2O2. Kinetic studies indicate that BSA-PtNPs have a much higher affinity for H2O2 than the NPs of other Pt-based peroxidase mimics. Furthermore, the BSA shell plays an important role in promoting the robust stability of PtNPs. Even in high ionic strength environment (2 M NaCl), the catalytic activity can be well preserved. These excellent properties make the BSA-PtNPs an ideal candidate for a wide range of potential applications as peroxidase mimics.