期刊
LASERS IN MEDICAL SCIENCE
卷 16, 期 1, 页码 44-51出版社
SPRINGER LONDON LTD
DOI: 10.1007/PL00011336
关键词
muscle injury; muscle regeneration; skeletal muscle; tibialis anterior; ACL myotoxin
We evaluated the effect on mice skeletal muscle regeneration of different doses (2.6, 8.4, and 25 J/cm(2)) of HeNe laser (lambda 632.8 nm; power, 2.6 mW; spot size, 0.007 cm(2)) applied directly to intact skin of injured muscle. Muscle injury was induced in both right and left Tibialis anterior (TA) muscles by ACL myotoxin (5 mg/kg). Right TA muscles were irradiated daily for 5 days while contralateral muscles received a sham treatment. Only the 2.6 J/cm(2) dose resulted in changes such as increased mitochondrial density and muscle fibre in the TA muscles as compared to sham groups (3280 +/- 704 mum(2) versus 2110 +/- 657 mum(2), p = 0.02). We concluded that the HeNe effect on mouse muscle regeneration is dose-specific: only 2.6 J/cm(2) increased muscle fibre area and mitochondrial density.
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