期刊
PULMONARY PHARMACOLOGY & THERAPEUTICS
卷 14, 期 3, 页码 183-191出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1006/pupt.2001.0285
关键词
protease-activated receptors (PARs); PAR2; inflammation; airways; trypsin; epithelium; mast cell tryptase; asthma; chronic obsturctive pulmonary disease
Protease-activated receptors (PARs) act as sensors for active extracellular serine proteases, Since serine proteases like mast cell tryptase are associated with inflammatory processes, PARs may represent novel pharmacological targets in airway diseases like asthma and chronic obstructive pulmonary disease. However, our present understanding of the physiological roles of PARs is in its infancy. In this review we highlight evidence for the involvement of PARs in airway disease and propose that these novel receptors may play mainly protective roles, (C) 2001 Academic Press.
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