期刊
IMMUNOLOGIC RESEARCH
卷 23, 期 2-3, 页码 229-234出版社
HUMANA PRESS INC
DOI: 10.1385/IR:23:2-3:229
关键词
mucosal immunity; reovirus; T cells; NF-kappa B; thymus-independent; cytotoxic T cells
类别
During the last three decades, immunologists and gastroenterologists have witnessed the formation of mucosal immunology as a discipline in biomedical science, and studies of reovirus infection have substantially contributed to this evolution. We have focused on mucosal T cell responses induced by reovirus in conventional, germfree, nude, and NF-kappaB deficient mice. Several major facets of T cell function in the immune responses to this mucosal pathogen have been examined, including viral selection of oligoclonal-T cells, extrathymic T cell development, and distinct signaling pathways used by CD8 sublineages. In addition, our findings with virus-specific T cells selected in the mucosa have suggested novel mechanisms for the rearrangement, selection, and expansion of TCR genes. With the increasing application of molecular tools, reovirus will continue to be a useful model pathogen to study mucosal immunology and will further our understanding of mucosal immunity in health and disease.
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