期刊
ANNUAL REVIEW OF MICROBIOLOGY
卷 55, 期 -, 页码 407-435出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.micro.55.1.407
关键词
bacterial pathogenesis; cell polarity; invasion; virulence; apical; basolateral
类别
资金
- NHLBI NIH HHS [HL55980] Funding Source: Medline
- NIAID NIH HHS [AI01636, AI24436, AI42806, AI44148] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL055980] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI044148, R01AI042806, R01AI024436] Funding Source: NIH RePORTER
Many pathogens must surmount an epithelial cell barrier in order to establish an infection. While much has been learned about the interaction of bacterial pathogens with cultured epithelial cells, the influence of cell polarity on these events has only recently been appreciated. This review outlines bacterial-host epithelial cell interactions in the context of the distinct apical and basolateral surfaces of the polarized epithelium that lines the lumens of our organs.
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