期刊
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
卷 41, 期 -, 页码 317-345出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.pharmtox.41.1.317
关键词
cADPR; inositol trisphosphate; ADP-ribosyl cyclase; CD38; Ca2+ stores; ryanodine receptor
资金
- NICHD NIH HHS [HD17484] Funding Source: Medline
- NIGMS NIH HHS [GM61568, GM60333] Funding Source: Medline
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [R01HD017484] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM061568, R01GM060333] Funding Source: NIH RePORTER
Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) are two Ca2+ messengers derived from NAD and NADP, respectively. Although NAADP is a linear molecule, structurally distinct from the cyclic cADPR, it is synthesized by similar enzymes, ADP-ribosyl cyclase and its homolog, CD38. The crystal structure of the cyclase has been solved and its active site identified. These two novel nucleotides have now been shown to be involved in a wide range of cellular functions including: cell cycle regulation in Euglena, a protist; gene expression in plants; and in animal systems, from fertilization to neurotransmitter release and long-term depression in brain. A battery of pharmacological reagents have been developed, providing valuable tools for elucidating the physiological functions of these two novel Ca2+ messengers. This article reviews these recent results and explores the implications of the existence of multiple Ca2+ messengers and Ca2+ stores in cells.
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