期刊
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
卷 41, 期 -, 页码 101-121出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.pharmtox.41.1.101
关键词
drug response; metabolism; polymorphism; SNP
资金
- NCI NIH HHS [CA21765, R37 CA36401, R01 CA78224] Funding Source: Medline
- NIGMS NIH HHS [U01 GM 61393] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA078224, P30CA021765, R37CA036401] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [U01GM061393] Funding Source: NIH RePORTER
There is great heterogeneity in the way humans respond to medications, often requiring empirical strategies to find the appropriate drug therapy for each patient (the art of medicine). Over the past 50 years, there has been great progress in understanding the molecular basis of drug action and in elucidating genetic determinants of disease pathogenesis and drug response. Pharmacogenomics is the burgeoning field of investigation that aims to further elucidate the inherited nature of interindividual differences in drug disposition and effects, with the ultimate goal of providing a stronger scientific basis for selecting the optimal drug therapy and dosages for each patient. These genetic insights should also lead to mechanism-based approaches to the discovery and development of new medications. This review highlights the current status of work in this field and addresses strategies that hold promise for future advances in pharmacogenomics.
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