期刊
JOURNAL OF ENZYME INHIBITION
卷 16, 期 6, 页码 527-533出版社
HARWOOD ACAD PUBL GMBH, TAYLOR & FRANCIS GROUP
DOI: 10.1080/14756360127567
关键词
PTK c-src; PTP SHP-1; inhibitors of PTKs
The inhibitory effect of gallic acid (3,4,5-trihydroxybenzoic acid), and its ester derivatives methyl, propyl, octyl and lauryl has been tested on the tyrosine kinase activity of affinity purified c-Src from human platelets, using the artificial substrate Poly (Glu.Na, Tyr) 4:1. When tested as inhibitor of the autophosphorylation of the enzyme and the phosphorylation of the protein tyrosine phosphatase SHP-1 by c-Src, lauryl gallate was found to be a more potent inhibitor than other widely used protein tyrosine kinase (PTK) inhibitors such as genistein and herbimycin A. However, lauryl gallate did not inhibit the activity of the serine threonine kinases protein kinase A (PKA) and casein kinase II (CKII) from rat brain.
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