期刊
CHEMBIOCHEM
卷 14, 期 5, 页码 633-638出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.201200764
关键词
Acinetobacter baumannii; enzymes; natural products; nonribosomal peptide synthetases; secondary metabolites; siderophores
资金
- Frankfurt Initiative of Microbial Sciences (FIMS) by the Goethe University Frankfurt
- excellence initiative of the Hessian Ministry of Science and Art (LOEWE research focus Insect Biotechnology)
Novel chatechol/hydroxamate siderophores (named fimsbactins) were identified in Acinetobacter baumannii ATCC 17978 and Acinetobacter baylyi ADP1. The major compound, fimsbactin A, was isolated from low-iron cultures of A. baylyi ADP1, and its chemical structure was elucidated by mass spectrometry, and detailed 1H, 13C and 15N NMR spectroscopy. From inverse feeding experiments following HPLC-MS analysis, the structures of five additional derivatives were elucidated. The gene cluster encoding the fimsbactin synthetase (fbs) was identified in both genomes, and mutants in fbs genes in A. baylyi were analyzed, thus allowing prediction of the fimsbactin biosynthesis pathway.
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