期刊
CHEMBIOCHEM
卷 14, 期 5, 页码 564-567出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.201300037
关键词
biochemistry; biosynthesis; patellamides; selenazolines
资金
- Leverhulme Trust [RPG-2012-504]
- Wellcome Trust [086036]
- BBSRC [BB/H001212/1, BB/K015508/1, BB/H005447/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/K015508/1, BB/H005447/1, BB/H001212/1, 1098674] Funding Source: researchfish
Ringing the changes: Selenazolines have applications in medicinal chemistry, but their synthesis is challenging. We report a new convenient and less toxic route to these heterocycles that starts from commercially available selenocysteine. The new route depends on a heterocyclase enzyme that creates oxazolines and thiazolines from serines/threonines and cysteines.
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