期刊
CHEMBIOCHEM
卷 13, 期 14, 页码 1990-2001出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.201200400
关键词
DNA structures; fluorescence spectroscopy; fluorescent probes; FRET; nucleic acids
资金
- Swedish Research Council (VR)
- Danish Council for Independent Research and Natural Sciences (FNU)
Forster resonance energy transfer (FRET) is a powerful tool for monitoring molecular distances and interactions at the nanoscale level. The strong dependence of transfer efficiency on probe separation makes FRET perfectly suited for on/off experiments. To use FRET to obtain quantitative distances and three-dimensional structures, however, is more challenging. This review summarises recent studies and technological advances that have improved FRET as a quantitative molecular ruler in nucleic acid systems, both at the ensemble and at the single-molecule levels.
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