期刊
JOURNAL OF IMMUNOLOGY
卷 166, 期 1, 页码 313-321出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.166.1.313
关键词
-
类别
资金
- NATIONAL EYE INSTITUTE [U01EY007021, R01EY011983, T32EY007145, U10EY007021] Funding Source: NIH RePORTER
Peripheral tolerance occurs after intraocular administration of Ag and is dependent on an increase in splenic NKT cells. New data here show that macrophage inflammatory protein-2 (MIP-2) is selectively up-regulated in tolerance-conferring APCs and serves to recruit NKT cells to the splenic marginal zone, where they form clusters with APCs and T cells. In the absence of the high-affinity receptor for MIP-2 las in CXCR2-deficient mice) or in the presence of a blocking Ab to MIP-2, peripheral tolerance is prevented, and Ag-specific T regulatory cells are not generated. Understanding the regulation of lymphocyte traffic during tolerance induction may lead to novel therapies for autoimmunity, graft acceptance, and tumor rejection.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据