期刊
NEUROIMAGE
卷 13, 期 1, 页码 210-217出版社
ACADEMIC PRESS INC
DOI: 10.1006/nimg.2000.0710
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资金
- NATIONAL EYE INSTITUTE [R01EY012148] Funding Source: NIH RePORTER
- NEI NIH HHS [EY00379, EY12148] Funding Source: Medline
Many behavioral paradigms involve temporally overlapping sensory, cognitive, and motor components within a single trial The complex interplay among these factors makes it desirable to separate the components of the total response without assumptions about shape of the underlying hemodynamic response. We present a method that does this. Four conditions were studied in four subjects to validate the method. Two conditions involved rapid event-related studies, one with a low-contrast (5%) flickering checkerboard and another with a high-contrast (95%) checkerboard Zn the third condition, the same high-contrast checkerboard was presented with widely spaced trials. Finally, multicomponent trials were formed from temporally adjacent low-contrast and high-contrast stimuli. These trials were presented as a rapid event-related study. Low-contrast stimuli presented in isolation (partial trials) made it possible to uniquely estimate both the low-contrast and high-contrast responses. These estimated responses matched those measured in the first three conditions, thereby validating the method. Nonlinear interactions between adjacent low-contrast and high-contrast responses were shown to be significant but weak in two of the four subjects. (C) 2001 Academic Press.
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