期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 83, 期 1, 页码 31-40出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0162-0134(00)00133-1
关键词
palladium(II) complexes; platinum(II) complexes; dithiocarbamate; cytotoxic activity
The [M(ESDT)Cl](n) (M=Pd or Pt; ESDT=EtO2CCH2(CH3)NCS2-, methylamino-acetic acid ethyl ester-dithiocarboxylate) species have been reacted with various amines (py, pyridine: PrNH2, n-propylamine; c-BuNH2, cyclobutylamine; en, ethylenediamine) in dichloromethane or chloroform with the aim to obtain mixed ligand complexes. The neutral complexes [M(ESDT)(L)CI] (L=py, PrNH2 or c-BuNH2) and the ionic species ([M(ESDT)(L)(2)]Cl and [M(ESDT)(En)]Cl) have been isolated, and characterized by IR and proton NMR spectroscopies. The crystal structure of [Pd(ESDT)(PrNH2)Cl] has been determined by X-ray crystallography. The behaviour of the complexes in various solvents was described on the basis of the proton NMR spectra. The complexes and the dithiocarbamato intermediates have been tested for in vitro cytostatic activity against human leukemic HL-60 and HeLa cells. (C) 2001 Elsevier Science B.V, All rights reserved.
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