期刊
CHEMBIOCHEM
卷 10, 期 3, 页码 445-+出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.200800762
关键词
AFM; amyloid; inhibitors; IR spectroscopy; resveratrol
资金
- Deutsche Forschungsgemeinschaft
- Fonds der Chemischen Industrie
The red wine compound resveratrol can effectively inhibit the formation of IAPP amyloid that is found in type II diabetes. Our in vitro inhibition results do not depend on the antioxidant activity of resveratrol. Further, the markedly enhanced cell survival in the presence of resveratrol also indicates that the small oligomeric structures that are observed during beta-sheet formation are not toxic and could be off-pathway assembly products.
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