期刊
CHEMBIOCHEM
卷 10, 期 18, 页码 2893-2899出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.200900587
关键词
carbohydrates; glycoconjugates; oligosaccharides; Streptococcus pneumoniae; synthetic vaccines
资金
- NSF [CHE-0547566]
- NIH [Al-067494, Al-031473, Al-30021]
The first synthesis of the newly discovered oligosaccharide of pneumococcal serotype 6C and its spacer-containing analogue is reported. Conjugation of the spacer-containing oligosaccharides of pneumococcal saccharides 6A, 6B, 6C and derivatives thereof with bovine serum albumin (BSA) protein carrier was carried out by using squaric-acid approach to obtain the oligosaccharide-protein conjugates in excellent yields. The conjugates have been tested with a rabbit antiserum pool (Pool B) used for pneumococcal serotyping. The results showed that synthetic carbohydrate conjugates express epitopes found in native capsular polysaccharides of serotypes 6A, 6B, and 6C.
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