期刊
CHEMICAL COMMUNICATIONS
卷 -, 期 10, 页码 867-880出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b100070p
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The diterpenoid natural product taxol, first discovered in the 1960's has proved to be the most important new anticancer drug introduced in the last ten years. A brief history of taxol's development from laboratory curiosity to blockbuster drug is followed by a summary of its chemistry, including an overview of the six completed syntheses of taxol. The review concludes with a discussion of its bioactivity as a promoter of tubulin polymerization and as a drug.
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