期刊
JOURNAL OF VIROLOGY
卷 75, 期 2, 页码 1031-1038出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.75.2.1031-1038.2001
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Adenovirus infection inhibits synthesis and processing of rRNA and redistributes nucleolar antigens, Adenovirus protein V associates with nucleoli in infected cells. This study delineates regions of protein V independently capable of nucleolar targeting. Also, evidence is presented that protein V has the unique property of relocating nucleolin and B23 to the cytoplasm when transiently expressed on its own in uninfected cells. Point mutation analysis indicates a role for the C terminus of protein V in the redirection of nucleolin and B23 to the cytoplasm. This is the first time an adenovirus protein has been shown to have a direct effect on nucleolar antigens in isolation from viral infection. Moreover, adenovirus protein V is the first protein demonstrated to be capable of redirecting nucleolin and B23 to the cytoplasm.
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