期刊
JOURNAL OF NEUROSCIENCE
卷 21, 期 1, 页码 -出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.21-01-j0003.2001
关键词
postsynaptic; photolysis; caged-carbachol; stratum radiatum; interneurons; acetylcholine
资金
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [Z01ES090089, ZIAES090089] Funding Source: NIH RePORTER
Alzheimer's disease (AD) is a human neurological disorder characterized by an increasing loss of cognitive function and the presence of extracellular neuritic plaques composed of the beta -amyloid peptide (A beta (1-42)). However, the link between these molecular correlates of AD and the loss of cognitive function has not been established. The pathology associated with AD includes the loss of basal forebrain cholinergic neurons, presynaptic terminals in the neocortex and hippocampus, and a decrease in the total amount of neuronal nicotinic acetylcholine receptors (nAChRs). This leads to the hypothesis that failure in the cholinergic system underlies the dementia seen in AD. Cognitive performance has been linked to nAChR function in the hippocampus, and the interneurons expressing nAChRs coordinate the activity of large numbers of principal cells and therefore have a powerful role in the regulation of hippocampal activity. We have found that A beta (1-42) inhibits whole-cell and single-channel nicotinic currents from rat hippocampal interneurons by directly blocking the postsynaptic nAChR channels at concentrations as low as 100 nM. This inhibition appears specific for peptide sequence and neuronal nAChRs, and the magnitude of A beta (1-42) inhibition is dependent on the nAChR channel subtype expressed. Thus, chronic inhibition of cholinergic signaling by A beta (1-42) could contribute to the cognitive deficits associated with AD.
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