期刊
CHEMBIOCHEM
卷 10, 期 12, 页码 1920-1938出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.200900208
关键词
biosynthesis; carbohydrates; glycoconjugates; glycosylation; organic synthesis
资金
- Natural Sciences and Engineering Research Council of Canada
- Alberta Ingenuity Centre for Carbohydrate Science
- The University of Alberta
- Alberta Heritage Foundation for Medical Research
The thermodynamically less stable from of galactose-galactofurabise (Galf) - is essential for the viability of several pathogenic species of bacteria and protozoa but absent in this form in mammals, so the biochemical pathways by which Galf-containing glycans are assembled and catabolysed are attractive sites for drug action. This potential has led to increasing interest in the synthesis of molecules containing Galf residues, their subsequent use in studies directed towards understanding the enzymes that process these residues and the identification of potential inhibitors of these pathways. Major achievements of the past several years have included an in-depth understanding of the mechanism of UDP-galactopyranose mutase (UGM), the enzyme that produces UDP-Galf, which is the donor species for galactofuranosyltransferases. A number of methods for the synthesis of galactofyrabisudes have also been developed, and practitioners in the field now have many options for the inititation of a synthesis of glycoconjugates containing either alpha- or beta-Galf residues. UDP-Galf has also been prepared by a number of approaches, and it appears that a chemoenzymatic approach is currently the most viable method for producing multi-milligram amounts of this important intermediate. Recent advances both in the understanding of the mechanism of UGM and in the synthesis of galactofuranose and its derivatives are highlighted in this review.
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