期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 49, 期 1, 页码 142-145出版社
AMER CHEMICAL SOC
DOI: 10.1021/jf001052a
关键词
Apium graveolens; Umbelliferae; celery; mosquitocidal; nematicidal; antifungal; sedanolide; senkyunolide
资金
- NCRR NIH HHS [1-S10-RR04750] Funding Source: Medline
- NATIONAL CENTER FOR RESEARCH RESOURCES [S10RR004750] Funding Source: NIH RePORTER
The methanolic extract of Apium graveolens seeds was investigated for bioactive compounds and resulted in the isolation and characterization of mosquitocidal, nematicidal, and antifungal compounds sedanolide (1), senkyunolide-N (2), and senkyunolide-J (3). Their structures were determined by IH and C-13 NMR spectral methods. Compounds 1-3 gave 100% mortality at 25, 100, and 100 mug mL(-1), respectively, on the nematode, Panagrellus redivivus. Compound 1 showed 100% mortality at 50 mug mL(-1) on nematode, Caenorhabditis elegans, and fourth-instar mosquito larvae, Aedes aegyptii. Also, it inhibited the growth of Candida albicans and Candida. parapsilasis at 100 mug mL(-1). Compounds 2 and 3 were isolated for the first time from A. graveolens. This is the first report of the mosquitocidal, nematicidal, and antifungal activities of compounds 1-3.
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