期刊
CHEMBIOCHEM
卷 9, 期 7, 页码 1159-1164出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.200800001
关键词
biological applications; fluorescent probes; image; mercury
A new mercury(II) near-infrared region fluorescent probe 3,9-dithia-6-monoazaundecane-tricarbocyanine has been designed and synthesized. It consists of two functional moieties: the tricarbocyanine performs as the near-infrared region fluorophore, and 1 the 3,9-dithia-6-monoazaundecane acts as the selected binding site for metal ions. The near-IR excitation and emission profiles of I the probe can minimize cell and tissue damage and ovoid native fluorescence from natural cellular species. It exhibits fluorescence increase upon the binding of the Hg2+ based on the inhibition of the photoinduced electron transfer quenching mechanism. Excellent sensitivity and selectivity for mercuric ions are observed with this probe. The value of the system is demonstrated by its use in monitoring the real-time uptake of Hg2+ within HepG2 cells and five day old zebrafish. The synthesis and remarkable properties of it help to extend the development of metal ions fluorescent probes for biological applications.
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