Transurethral resection of muscle-invasive bladder cancer: 10-year outcome

Purpose: To determine the 10-year outcome of patients with muscle-invasive bladder cancer treated by transurethral resection (TUR) alone. Patients and Methods: Of 432 newly evaluated patients with muscle-invasive bladder cancer, 151 were treated by standard radical cystectomy or by definitive TUR, if restaging TUR of the primary tumor site showed no (T0) or only non-muscle-invasive (T1) residual tumor, patients were followed-vp every 3 to 6 months thereafter for a minimum of 10 years and up to 20 years. primary end points of the study were disease-specific survival, survival with a bladder, frequency of recurrent invasive tumors in the bladder, and survival after salvage cystectomy. Results: The 10-year disease-specific survival was 76% of 99 patients who received TUR as definitive therapy (57% with bladder preserved) compared with 71% of 52 patients who had immediate cystectomy (P = .3), Of the 99 patients treated with TUR, 82% of 73 who had TO on restaging TUR survived versus 57% of the 26 patients who held residual T1 tumor on restaging TUR (p = .003), Thirty-four patients (34%) relapsed in the bladder with a new muscle-invasive tumor, 18 (53%) were successfully treated with salvage therapy via cystectomy, and 16 patients (16%) died of disease. Conclusion: Radical TUR for muscle-invasive bladder cancer is ct successful bladder-sparing therapeutic strategy in selected patients who have no residual tumor on a repeat vigorous resection of the primary tumor site. J Clin Oncol 19:89-93. (C) 2001 by American Society of Clinical Oncology.