期刊
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
卷 67, 期 1, 页码 15-21出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.67.1.15-21.2001
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资金
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [R01DE009082] Funding Source: NIH RePORTER
- NIDCR NIH HHS [R01 DE009082, R01 DE09082] Funding Source: Medline
Strains of Streptococcus mutans produce at least three mutacins, I, II, and III. Mutacin n is a member of subgroup ATI in the lantibiotic family of bacteriocins, and mutacins I and III belong to subgroup AI in the lantibiotic family. In this report, we characterize two mutacins produced by UA140, a group I strain of S. mutans, One is identical to the lantibiotic mutacin I produced by strain CH43 (F, Qi et al., Appl, Environ, Microbiol, 66:3221-3229, 2000); the other is a nonlantibiotic bacteriocin, which we named mutacin IV,Mutacin IV belongs to the two-peptide, nonlantibiotic family of bacteriocins produced by gram-positive bacteria. Peptide A, encoded by gene nlmA, is 44 amino acids (aa) in size and has a molecular mass of 4,169 Da; peptide B, encoded by nlmB, is 49 aa in size and has a molecular mass of 4,826 Da, Both peptides derive from prepeptides with glycines at positions -2 and -1 relative to the processing site. Production of mutacins I and IV by UA140 appears to be regulated by different mechanisms under different physiological conditions. The significance of producing two mutacins by one strain under different conditions and the implication of this property in terms of the ecology of S, mutans in the oral cavity are discussed.
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