期刊
NEPHROLOGY DIALYSIS TRANSPLANTATION
卷 16, 期 -, 页码 67-69出版社
OXFORD UNIV PRESS
DOI: 10.1093/ndt/16.suppl_1.67
关键词
chronic renal failure; hypertension; metoprolol; moxonidine; sympathetic activity
In the past, it had been presumed that hypertension in chronic renal disease can be explained by the dual effects of sodium retention and inappropriate activity of the renin-angiotensin system. Recent experimental and clinical data provide strong evidence that the increase in blood pressure is to a large part due to sympathetic overactivity which is triggered by afferent signals emanating from the kidney and resetting sympathetic tone by stimulation of hypothalamic centres. The sequelae of sympathetic overactivity extend beyond their effects on blood pressure and include accelerated progression of renal failure and presumably increased cardiac arrhythmia.
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