期刊
NATURE MEDICINE
卷 7, 期 1, 页码 101-107出版社
NATURE AMERICA INC
DOI: 10.1038/83231
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资金
- NCI NIH HHS [5 T32CA09547-13, 5P01 CA49712-08, 1KO8CA8790101, R24 CA83060] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R24CA083060, K08CA087901, T32CA009547, P01CA049712] Funding Source: NIH RePORTER
The transcription factor, early growth response protein 1 (ECR1), is overexpressed in a majority of human prostate cancers and is implicated in the regulation of several genes important for prostate tumor progression. Here we have assessed the effect of Egr1 deficiency on tumor development in two transgenic mouse models of prostate cancer (CR2-T-Ag and TRAMP). Using a combination of high-resolution magnetic resonance imaging and histopathological and survival analyses, we show that tumor progression was significantly impaired in Egr1(-/-) mice. Tumor initiation and tumor growth rate were not affected by the lack of Egr1; however, Egr1 deficiency significantly delayed the progression from prostatic intra-epithelial neoplasia to invasive carcinoma. These results indicate a unique role for Egr1 in regulating the transition from localized, carcinoma in situ to invasive carcinoma.
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