期刊
NEUROSCIENCE
卷 102, 期 4, 页码 715-721出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0306-4522(00)00584-4
关键词
inhibition; calcium spikes; spines
资金
- NIMH NIH HHS [MH12403, MH54671] Funding Source: Medline
- NINDS NIH HHS [NS34994] Funding Source: Medline
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS034994] Funding Source: NIH RePORTER
Dendrites of pyramidal cells perform complex amplification and integration (review ed in Refs 5, 9, 12 and 20), The presence of a large proximal apical dendrite has been shown to have functional implications for neuronal firing patterns(13) and under a variety of experimental conditions, the largest increases in intracellular Ca2+ occur in the apical shaft(4,8,15,16,19,21-23) An important step in understanding the functional role of the proximal apical dendrite is to describe the nature of synaptic input to this dendritic region. Using light and electron microscopic methods combined with in vivo labeling of rat hippocampal CAI pyramidal cells, we examined the total number of GABAergic and non-GABAergic inputs converging onto the first 200 mum of the apical trunk. The number of spines associated with excitatory terminals increased from <0.2 spines/m adjacent to the soma to 5.5 spines/mum at 200 pm from the soma, whereas the number of GABAergic, symmetric terminals decreased from 0.8/mum to 0.08/mum over the same anatomical region. GABAergic terminals were either parvalbumin-, cholecystokinin- or vasointestinal peptide-immunoreactive, These findings indicate that the apical dendritic trunk mainly receives synaptic input from GABAergic interneurons. GABAergic inhibition during network oscillation may serve to periodically isolate the dendritic compartments from the perisomatic action potential generating sites. (C) 2001 IBRO, Published by Elsevier Science Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据