期刊
BREAST CANCER RESEARCH AND TREATMENT
卷 66, 期 2, 页码 165-170出版社
KLUWER ACADEMIC PUBL
DOI: 10.1023/A:1010644217648
关键词
anaerobic bacteria; Bifidobacterium longum; gene therapy; hypoxia; vector
类别
A fundamental obstacle in cancer gene therapy is the specific targeting of therapy directly to a solid tumor, and no systemic delivery system yet exists. A strain of domestic bacteria, Bifidobacteriumlongum, which is nonpathogenic and anaerobic, selectively localized to and proliferated in 7,12-dimethylbenz[a]anthracene-induced rat mammary tumors after systemic application. We further ascertained the tumor specificity of genetically engineered, as well as wild-type, Bifidobacterium longum. This is the first demonstration that Bifidobacterium longum can be utilized as a specific gene delivery vector for gene therapy on solid breast tumors.
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