期刊
BIOTECHNOLOGY LETTERS
卷 23, 期 2, 页码 157-161出版社
KLUWER ACADEMIC PUBL
DOI: 10.1023/A:1010356231673
关键词
clavulanic acid; empirical model; experimental design; medium composition; Streptomyces clavuligerus
Among four different commercially available nitrogen sources containing soybean derivatives, a protein extract of soybean gave the highest yield for clavulanic acid production by Streptomyces clavuligerus. A statistical method based on factorial design of experiments was applied to optimise the medium. An empirical model was obtained by applying response surface statistical analysis. The analysis of variance showed that concentrations of protein extract of soybean and glycerol and the interaction between these two variables were significant at 95% level of confidence. The maximum clavulanic acid concentration obtained in 72 h was 1.2 g l(-1).
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