期刊
JOURNAL OF NATURAL PRODUCTS
卷 64, 期 1, 页码 117-121出版社
AMER CHEMICAL SOC
DOI: 10.1021/np0002379
关键词
-
资金
- NCI NIH HHS [N01-CO-56000] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [Z01DK032102] Funding Source: NIH RePORTER
- OFFICE OF THE DIRECTOR, NCI [N01CO056000] Funding Source: NIH RePORTER
Microspinosamide (1), a new cyclic depsipeptide incorporating 13 amino acid residues, was isolated from extracts of an Indonesian collection of the marine sponge Sidonops microspinosa. Its structure was elucidated by extensive NMR and mass spectral analyses, and by chemical degradation and derivatization studies. The tridecapeptide 1 incorporates numerous uncommon amino acids, and it is the first naturally occurring peptide to contain a beta -hydroxy-p-bromophenylalanine residue. Microspinosamide (1) inhibited the cytopathic effect of HIV-1 infection in an XTT-based in vitro assay with an EC50 value of approximately 0.2 mug/mL.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据