期刊
NATURE NEUROSCIENCE
卷 4, 期 1, 页码 72-77出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/82924
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资金
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS025616] Funding Source: NIH RePORTER
- NINDS NIH HHS [NS 25616] Funding Source: Medline
We found a class of lamina I spinothalamic tract (STT) neurons selectively excited by iontophoretic histamine. The responses of this class of neurons parallel the pure itching sensation this stimulus elicits in humans, and match the responses of peripheral C-fibers that have similar selectivity. These neurons have distinct central conduction velocities and thalamic projections, indicating that they constitute a unique subset of STT neurons. These findings can explain why a lesion of the lateral STT disrupts itch along with pain and temperature sensations. Our findings provide strong evidence that itch is subserved by specific neural elements both peripherally and centrally.
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