期刊
CHANNELS
卷 8, 期 2, 页码 118-123出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/chan.27978
关键词
G-protein coupled receptor; NMDA receptor; adrenergic receptor; alpha1R; gap junction; hemichannel; ionotropic receptor; pannexin; purinergic
资金
- National Institutes of Health [HL088554, HL107963]
Pannexins are a class of plasma membrane spanning proteins that presumably form a hexameric, non-selective ion channel. Although similar in secondary structure to the connexins, pannexins notably do not form endogenous gap junctions and act as bona fide ion channels. The pannexins have been primarily studied as ATP-release channels, but the overall diversity of their functions is still being elucidated. There is an intriguing theme with pannexins that has begun to develop. In this review we analyze several recent reports that converge on the idea that pannexin channels (namely Panx1) can potentiate ligand-gated receptor signaling. Although the literature remains sparse, this emerging concept appears consistent between both ionotropic and metabotropic receptors of several ligand families.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据