期刊
CHANNELS
卷 6, 期 6, 页码 416-425出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/chan.22340
关键词
cartilage; chondrocyte; potassium channel; membrane potential; mechanotransduction
资金
- PetPlan Charitable Trust
- BBSRC
- Wellcome Trust [CVRT VS 0901, CVRT VS 1201]
- EPSRC
- Novartis
- Foundation for Science and Technology
- Waltham Centre for Pet Nutrition
- FCT (Fundacao para a Ciencia e a Tecnologia, Portugal)
- European Commission [HEALTH. 2012.2.4.5-2, 305815]
Chondrocytes are the resident cells of cartilage, which synthesize and maintain the extracellular matrix, and the range of known potassium channels expressed by these unique cells is continually increasing. Since chondrocytes are non-excitable, and do not need to be repolarized following action potentials, the function of potassium channels in these cells has, until recently, remained completely unknown. However, recent advances in both traditional physiology and omic technologies have enhanced our knowledge and understanding of the chondrocyte channelome. A large number of potassium channels have been identified and a number of putative, but credible, functions have been proposed. Members of each of the potassium channel subfamilies (calcium activated, inward rectifier, voltage-gated and tandem pore) have all been identified. Mechanotransduction, cell volume regulation, apoptosis and chondrogenesis all appear to involve potassium channels. Since evidence suggests that potassium channel gene transcription is altered in osteoarthritis, future studies are needed that investigate potassium channels as potential cellular biomarkers and therapeutic targets for treatment of degenerative joint conditions.
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