期刊
GENOMICS
卷 71, 期 1, 页码 110-117出版社
ACADEMIC PRESS INC
DOI: 10.1006/geno.2000.6419
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资金
- NATIONAL CANCER INSTITUTE [R01CA025951] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES008823] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [P50NS039764] Funding Source: NIH RePORTER
- NCI NIH HHS [CA25951] Funding Source: Medline
- NIA NIH HHS [AG05128] Funding Source: Medline
- NIEHS NIH HHS [ES08823] Funding Source: Medline
- NINDS NIH HHS [NS39764] Funding Source: Medline
The paternally expressed Peg3 gene in mice encodes an unusual Kruppel-type zinc finger protein implicated in critical cellular and behavioral functions including growth, apoptosis, and maternal nurturing behavior. Methylation and expression analyses were used to determine whether PEG3 on chromosome 19q13.4 is imprinted in humans. The PEG3 promoter is encompassed within a large CpG-rich region that is differentially methylated in fetal tissues. Furthermore, expression studies demonstrate that PEG3 is ubiquitously imprinted throughout development and postnatally. Multiple isoforms of the PEG3 gene, including a novel transcript, are paternally expressed. These results are the first to show that human chromosome 19q13.4 contains an imprinted region. The imprinted status of PEG3 throughout life coupled with its neural expression and putative roles in regulating cell growth suggests that PEG3 may be a susceptibility locus for cancer as well as neurobehavioral deficits. (C) 2001 Academic Press.
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