期刊
CHANNELS
卷 2, 期 1, 页码 51-58出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/chan.2.1.6047
关键词
transporter; glutamate; chloride channel; leak; slip; aspartate
资金
- Australian National Health and Medical Research Council [ID307604, ID358779]
Glutamate transporters are unusual proteins in that they can function as both a transporter and a chloride channel. With the recent determination of the crystal structure of an archaeal aspartate transporter it is now possible to begin to put together a physical picture of how these proteins are able to carry out their dual functions. In this review we shall discuss our current understanding of the functional states of glutamate transporters and how they may arise. We will also discuss some of the alternate conducting states of glutamate transporters and provide definitions of the various states.
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