期刊
JOURNAL OF FOOD SCIENCE
卷 80, 期 4, 页码 H869-H874出版社
WILEY
DOI: 10.1111/1750-3841.12815
关键词
acrylamide (AA); berry powder; general toxicity; genetic toxicity; protection; reproductive toxicity
资金
- Natl. Natural Science Foundation [81102152]
- Natl. Basic Research Program of China (973 Program) [2012CB720805]
- Program for New Century Excellent Talents in Univ. [NCET-12-0520]
- Special Fund for Agro-scientific Research in the Public Interest [201303073]
Berries are dietary plants with high antioxidant activity. The aim of this study is to investigate the protective effect of berries (strawberry, grape, and blueberry) against the acrylamide (AA)-induced general toxicity, genotoxicity, and reproductive toxicity in mice model, respectively. Mice were treated with 50 mg/kg b.w./day AA intraperitoneal injection for 5 d after feeding control diet or diet containing freeze-dried strawberry, grape, and blueberry powder. The results showed that AA induced a significant general toxicity, genotoxicity, and reproductive toxicity in mice. Compared with the control diet, the diets containing berries could reverse the AA-induced alterations in liver antioxidant enzymes activities (P < 0.05). Moreover, the AA-induced genotoxicity could be prevented by the diet containing berries. The DNA damage in the lymphocyte and liver cells and the micronucleus formation in bone marrow cell were significantly alleviated (P < 0.05). Meanwhile, the mice fed with diets containing berries showed a recovery in the sperm count, the sperm activity rate, sperm motility parameters, and the abnormal sperm rate (P < 0.05). Berry powders have remarkable intervention against the AA-induced general toxicity, genotoxicity, reproductive toxicity. Abundant phenolics, especially anthocyanins, may contribute to the intervention. Practical Application The present study would provide an easy way to lower health risk for occupational exposure and high dietary exposure to AA through diet enriched with berries. Especially, this is important to better improve human health when considering the possibility of using foods enriched with phenolics for prevention of the toxicity of exogenous pollutants.
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