4.1 Article Proceedings Paper

Cyclohexene nucleic acids (CeNA) form stable duplexes with RNA and induce RNase H activity

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NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
卷 20, 期 4-7, 页码 785-788

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MARCEL DEKKER INC
DOI: 10.1081/NCN-100002430

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Cyclohexene nucleic acids (CeNA) were synthesized using classical phosporamidite chemistry. Incorporation of a cyclohexene nucleo-side in a DNA chain leads to an increase in stability of the DNA/RNA duplex. CeNA is stable against degradation in serum. A CeNA/RNA hybrid is able to activate E. Coli RNase H, resulting in cleavage of the RNA strand.

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