期刊
PURE AND APPLIED CHEMISTRY
卷 73, 期 1, 页码 193-198出版社
INT UNION PURE APPLIED CHEMISTRY
DOI: 10.1351/pac200173010193
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A solvent-free approach for organic synthesis is described which involves microwave (MW) exposure of neat reactants (undiluted) either in the presence of a catalyst or catalyzed by the surfaces of inexpensive and recyclable mineral supports such as alumina, silica, clay, or doped surfaces, namely, Fe(NO3)(3)-clay (clayfen). Cu(NO3)(2)-clay (claycop), NH2OH-clay PhI(OAc)(2)-alumina, NaIO4-silica, MnO2-silica, and NaBH4-clay. A variety of deprotection, condensation, cyclization, oxidation, and reduction reactions are presented including the efficient one-pot assembly of heterocyclic molecules from in situ generated intermediates such as enamines and alpha -tosyloxyketones. The application of this solvent-free MW approach ro multicomponent reactions is highlighted that can be adapted for high-speed parallel synthesis of the library of dihydropyrimidine-2(1H)-ones and imidazo [1,2-a]annulated pyridines, pyrazines, and pyrimidines.
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