期刊
PAIN
卷 89, 期 2-3, 页码 181-186出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0304-3959(00)00370-5
关键词
nerve growth factor; dorsal root ganglion; vanilloid receptor; calcitonin gene related peptide release
Nerve growth factor (NGF) regulates the nociceptive properties including sensitivity to capsaicin of a subset of dorsal root ganglion neurons, which express the high-affinity NGF receptor, trkA. Capsaicin sensitivity co-localizes with the expression of a cloned capsaicin receptor, vanilloid receptor type 1 (VR-1), which displays properties similar to the native capsaicin response. To determine whether VP-1 mRNA levels are regulated by NGF, VP-1 mRNA levels and the ability to respond to capsaicin by release of the neuropeptide calcitonin gene related peptide (CGRP) were measured as a function of NGF concentration in cultures of adult dorsal root ganglion neurons. NGF treatment increased both VP-1 mRNA expression and capsaicin evoked release of CGRP. These effects: were inhibited by treatment with the trkA inhibitor k252a. (C) 2001 International Association for the Study of Pain. Published by Elsevier Science B.V. All rights reserved..
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