期刊
NATURE IMMUNOLOGY
卷 2, 期 1, 页码 51-57出版社
NATURE AMERICA INC
DOI: 10.1038/83168
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- NIAID NIH HHS [AI07323] Funding Source: Medline
- NIGMS NIH HHS [GM07185] Funding Source: Medline
Lipopolysaccharide (LPS) induction of the gene encoding interleukin 12 p40 requires remodeling of a promoter-encompassing nucleosome and the Toll-like receptor (TLR)-mediated activation of a c-Re1-containing complex. Analysis of TLR4-mutant mice revealed that remodeling requires TLR signaling. However, Re1 proteins and other proteins required for transcription of an integrated p40 promoter were insufficient for remodeling. c-Re1 was also unnecessary for remodeling, as remodeling was observed in c-Re1(-/-) macrophages, which lack p40 transcripts. These results suggest that remodeling requires TLR signaling pathways that diverge from the c-Re1 activation pathways. The factors that stimulate remodeling may represent, therefore, newly identified targets of TLR signaling and of agents that regulate inflammatory responses and T(H)1 development.
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